NFL Week 5 is upon us, and we’ve got a thrilling slate of games lined up. The Cincinnati Bengals will try to pull off an upset against Lamar Jackson and the Baltimore Ravens, the Denver Broncos aim for back-to-back victories against a Davante Adams-less Las Vegas Raiders, and Justin Fields will fight to lock down the Pittsburgh Steelers’ starting quarterback job with a prime-time win over the Dallas Cowboys.
As always, we’ve gathered all the best picks, predictions, and gambling content from CBSSports.com and SportsLine in one place. Get picks against the spread from our CBS Sports experts, along with feature content from SportsLine experts and the SportsLine Projection Model. Plus, you’ll find best bets, survivor picks, and more. Ready? Let’s dive in!
All NFL odds via SportsLine consensus odds.
Baltimore Ravens at Cincinnati Bengals
Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+
Opening Line: Bengals -1.5, O/U 46.5
Key Insight:
The Bengals are struggling against the run, which could be disastrous against Baltimore’s three-headed rushing attack. Lamar Jackson has a long history of explosive performances versus this defense, averaging 5.0 yards per carry against them last year. Joe Burrow, on the other hand, has struggled in recent matchups, going 1-3 against Baltimore over the last two seasons with an average of 5.9 yards per attempt and an 85.3 passer rating. Baltimore is 4-2 ATS in their last six at Cincinnati and 7-3 ATS on the road since last season. Ravens -2.5 is a top bet this week.
Buffalo Bills at Houston Texans
Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+
Opening Line: Texans -1.5, O/U 48
Key Insight:
Houston is averaging a concerning 10 penalties per game, while Buffalo is much more disciplined. In this quarterback showdown between Josh Allen and C.J. Stroud, those mistakes could prove costly for Houston. Both teams are explosive offensively, so expect a high-scoring affair. With Allen and Stroud as MVP candidates, fantasy owners should start all the key players in this one.
Carolina Panthers at Chicago Bears
Time: Sunday, 1 p.m. ET (FOX), stream on fubo (try for free)
Opening Line: Bears -5.5, O/U 42
Key Insight:
Things are starting to click for the Bears’ offense. Quarterback Caleb Williams is coming off his best game of the season, and the Panthers, allowing a league-worst 32.3 points per game, provide a favorable matchup. While Andy Dalton has stabilized Carolina’s offense, the Bears’ defense, ranked just outside the top 10 in fewest yards per play allowed, will be tough to beat. Chicago is 7-0 SU and 6-1 ATS at home in their last seven games, so expect them to cover.
Cleveland Browns at Washington Commanders
Time: Sunday, 1 p.m. ET (FOX), stream on fubo (try for free)
Opening Line: Browns -2.5, O/U 43.5
Key Insight:
SportsLine senior analyst Larry Hartstein likes the Browns to cover this week. Despite their offensive struggles, Cleveland’s defense will present the biggest challenge Jayden Daniels has faced. The Browns’ offense has a chance to rebound against the Commanders’ shaky defense, and this one should stay close. Taking Cleveland with the points is a smart play.
Indianapolis Colts at Jacksonville Jaguars
Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+
Opening Line: Jaguars -2.5, O/U 47
Key Insight:
The Colts haven’t won in Jacksonville since 2014, but the Jaguars are in a must-win situation at 0-4. With uncertainty at quarterback for Indianapolis, Jacksonville is likely to grab their first victory of the season.
Miami Dolphins at New England Patriots
Time: Sunday, 1 p.m. ET (FOX), stream on fubo (try for free)
Opening Line: Dolphins -3.5, O/U 45
Key Insight:
The Dolphins are winless without Tua Tagovailoa, and their offense has struggled mightily. Meanwhile, the Patriots’ defense is strong, despite some offensive struggles of their own. This should be a low-scoring game, and the Patriots are likely to win at home.
Arizona Cardinals at San Francisco 49ers
Time: Sunday, 4:05 p.m. ET (FOX), stream on fubo (try for free)
Opening Line: 49ers -9.5, O/U 47
Key Insight:
San Francisco has dominated this matchup, winning four straight and putting up huge numbers in those games. After the Cardinals’ weak performance last week, expect the 49ers to win big once again.
Las Vegas Raiders at Denver Broncos
Time: Sunday, 4:05 p.m. ET (FOX), stream on fubo (try for free)
Opening Line: Broncos -1, O/U 41
Key Insight:
The Broncos’ defense has been stellar, leading the league in several key categories, including sacks and pressure rate. The Raiders are without Davante Adams, which will only add to their struggles. Denver should come away with the win, thanks to their defense.
Green Bay Packers at Los Angeles Rams
Time: Sunday, 4:25 p.m. ET (CBS), stream on Paramount+
Opening Line: Rams -1.5, O/U 48.5
Key Insight:
Jordan Love showed flashes of his potential in the Packers’ comeback attempt last week, and he’ll have another chance to shine against a Rams defense that’s been porous. Expect a strong showing from Green Bay’s ground game as the Rams rank last in rushing defense.
New York Giants at Seattle Seahawks
Time: Sunday, 4:25 p.m. ET (CBS), stream on Paramount+
Opening Line: Seahawks -3.5, O/U 43
Key Insight:
The Giants will be well-rested after playing last Thursday, while the Seahawks are coming off a Monday night game. With Seattle’s banged-up defense, the Giants have a chance to hang around, but Seattle should pull out the win.
Dallas Cowboys at Pittsburgh Steelers
Time: Sunday, 8:20 p.m. ET (NBC), stream on fubo (try for free)
Opening Line: Cowboys -1.5, O/U 43
Key Insight:
R.J. White, an NFL expert on SportsLine, leans towards the under in this matchup. He’s been on a hot streak with his Steelers spread picks, so check out his full breakdown on SportsLine.
New Orleans Saints at Kansas City Chiefs
Time: Monday, 8:15 p.m. ET (ESPN), stream on fubo (try for free)
Opening Line: Chiefs -8, O/U 44.5
Key Insight:
The Chiefs look to stay unbeaten as they host the Saints on “Monday Night Football.” After losing two straight, the Saints face a tough test against a Chiefs team that continues to dominate.